Supply Afoxolaner CAS 1093861-60-9 with Very High Quality And Best Price

Product Description

afoxolaner insecticide for animal with Best Price

Common Name	Afoxolaner
CAS Number	1093861-60-9	Molecular Weight	625.87000
Density	N/A	Boiling Point	N/A
Molecular Formula	C₂₆H₁₇ClF₉N₃O₃	Melting Point	N/A
MSDS	N/A	Flash Point	N/A

Use of Afoxolaner

Afoxolaner is an orally active isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect γ-aminobutyric acid receptor (GABA) and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod[1][2].

Afoxolaner Biological Activity

Description	Afoxolaner is an orally active isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect γ-aminobutyric acid receptor (GABA) and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Chloride Channel Research Areas >> Infection Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor
In Vivo	A single oral treatment with a dose approaching the minimum effective dose of afoxolaner (2.5mg/kg) eliminated the pre-existing infestations of I. scapularis ticks and controlled weekly re-infestations, with efficacy between 98% and 100% recorded until Day 23 and 94% at Day 30[1].
References	[1]. Mitchell EB, et al. Efficacy of afoxolaner against Ixodes scapularis ticks in dogs.Vet Parasitol. 2014 Apr 2;201(3-4):223-5. [2]. Beugnet F, et al. Afoxolaner against fleas: immediate efficacy and resultant mortality after short exposure on dogs.Parasite. 2014;21:42.

Chemical & Physical Properties

Molecular Formula	C₂₆H₁₇ClF₉N₃O₃
Molecular Weight	625.87000
Exact Mass	625.08100
PSA	79.79000
LogP	6.71990

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