Buy High quality 99% Medetomidine 86347-14-0 alibaba and Made in China

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Spcification 


Common Name Medetomidine
CAS Number 86347-14-0 Molecular Weight 200.279
Density 1.1±0.1 g/cm3 Boiling Point 381.9±11.0 °C at 760 mmHg
Molecular Formula C13H16N2 Melting Point 151.5 - 152.5ºC
MSDS N/A Flash Point 191.3±5.7 °C

Use of Medetomidine


Medetomidine(Domtor) is a potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). IC50 value:Target: α2-adrenoceptorMedetomidine displays greater selectivity over α1-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Medetomidine inhibits twitch response in electrically stimulated mouse vas deferens (pD2 = 9.0). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.

Medetomidine Biological Activity

Description Medetomidine(Domtor) is a potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). IC50 value:Target: α2-adrenoceptorMedetomidine displays greater selectivity over α1-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Medetomidine inhibits twitch response in electrically stimulated mouse vas deferens (pD2 = 9.0). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.
Related Catalog
References

[1]. Wenger S, Hoby S, Wyss F, Adami C, Wenker C. Anaesthesia with medetomidine, midazolam and ketamine in six gorillas after premedication with oral zuclopenthixol dihydrochloride. Vet Anaesth Analg. 2012 Aug 8. doi: 10.1111/j.1467-2995.2012.00761.x.

[2]. Gerritsmann H, Stalder GL, Seilern-Moy K, Knauer F, Walzer C. Comparison of S(+)-ketamine and ketamine, with medetomidine, for field anaesthesia in the European brown hare (Lepus europaeus). Vet Anaesth Analg. 2012 Jul 13. doi: 10.1111/j.1467-2995.2012.

[3]. Kallio A, Koulu M, Scheinin H, Viikari J, Scheinin M. Acute effects of medetomidine, a selective alpha 2-adrenoceptor agonist, on anterior pituitary hormone and cortisol secretion in man. Acta Endocrinol (Copenh). 1988 Sep;119(1):11-5.

[4]. Virtanen R, Savola JM, Saano V, Nyman L. Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist. Eur J Pharmacol. 1988 May 20;150(1-2):9-14.

[5]. Stenberg D, Salvén P, Miettinen MV. Sedative action of the alpha 2-agonist medetomidine in cats. J Vet Pharmacol Ther. 1987 Dec;10(4):319-23.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 381.9±11.0 °C at 760 mmHg
Melting Point 151.5 - 152.5ºC
Molecular Formula C13H16N2
Molecular Weight 200.279
Flash Point 191.3±5.7 °C
Exact Mass 200.131348
PSA 28.68000
LogP 3.10
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.570
Storage condition -20°C


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