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Supply Afoxolaner CAS 1093861-60-9 with Very High Quality And Best Price
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Supply Afoxolaner CAS 1093861-60-9 with Very High Quality And Best Price Supply Afoxolaner CAS 1093861-60-9 with Very High Quality And Best Price
Supply Afoxolaner CAS 1093861-60-9 with Very High Quality And Best Price Supply Afoxolaner CAS 1093861-60-9 with Very High Quality And Best Price
Supply Afoxolaner CAS 1093861-60-9 with Very High Quality And Best Price Supply Afoxolaner CAS 1093861-60-9 with Very High Quality And Best Price
Supply Afoxolaner CAS 1093861-60-9 with Very High Quality And Best Price Supply Afoxolaner CAS 1093861-60-9 with Very High Quality And Best Price
Supply Afoxolaner CAS 1093861-60-9 with Very High Quality And Best Price Supply Afoxolaner CAS 1093861-60-9 with Very High Quality And Best Price

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Supply Afoxolaner CAS 1093861-60-9 with Very High Quality And Best Price

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Poultry Animals Afoxolaner, Afoxolane, Afoxolane supplier, cas1093861-60-9 - Multinpharma

  • 1093861-60-9

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  • 1093861-60-9

  • 1093861-60-9

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afoxolaner insecticide for animal with Best Price


Common Name Afoxolaner
CAS Number 1093861-60-9 Molecular Weight 625.87000
Density N/A Boiling Point N/A
Molecular Formula C26H17ClF9N3O3 Melting Point N/A
MSDS N/A Flash Point N/A

Use of Afoxolaner


Afoxolaner is an orally active isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect γ-aminobutyric acid receptor (GABA) and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod[1][2].

Afoxolaner Biological Activity

Description Afoxolaner is an orally active isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect γ-aminobutyric acid receptor (GABA) and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod[1][2].
Related Catalog
Signaling Pathways >> Membrane Transporter/Ion Channel >> Chloride Channel
Research Areas >> Infection
Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor
Signaling Pathways >> Neuronal Signaling >> GABA Receptor
In Vivo A single oral treatment with a dose approaching the minimum effective dose of afoxolaner (2.5mg/kg) eliminated the pre-existing infestations of I. scapularis ticks and controlled weekly re-infestations, with efficacy between 98% and 100% recorded until Day 23 and 94% at Day 30[1].
References

[1]. Mitchell EB, et al. Efficacy of afoxolaner against Ixodes scapularis ticks in dogs.Vet Parasitol. 2014 Apr 2;201(3-4):223-5.

[2]. Beugnet F, et al. Afoxolaner against fleas: immediate efficacy and resultant mortality after short exposure on dogs.Parasite. 2014;21:42.

 Chemical & Physical Properties


Molecular Formula C26H17ClF9N3O3
Molecular Weight 625.87000
Exact Mass 625.08100
PSA 79.79000
LogP 6.71990
pharmaceutical products 9 pharmaceutical products 90 pharmaceutical products 99




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