1093861-60-9
MT
1093861-60-9
1093861-60-9
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afoxolaner insecticide for Dog ,CAT animal with Best Price
Common Name | Afoxolaner | ||
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CAS Number | 1093861-60-9 | Molecular Weight | 625.87000 |
Density | N/A | Boiling Point | N/A |
Molecular Formula | C26H17ClF9N3O3 | Melting Point | N/A |
MSDS | N/A | Flash Point | N/A |
Description | Afoxolaner is an orally active isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect γ-aminobutyric acid receptor (GABA) and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod[1][2]. |
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Related Catalog | Signaling Pathways >> Membrane Transporter/Ion Channel >> Chloride Channel Research Areas >> Infection Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor |
In Vivo | A single oral treatment with a dose approaching the minimum effective dose of afoxolaner (2.5mg/kg) eliminated the pre-existing infestations of I. scapularis ticks and controlled weekly re-infestations, with efficacy between 98% and 100% recorded until Day 23 and 94% at Day 30[1]. |
References | [1]. Mitchell EB, et al. Efficacy of afoxolaner against Ixodes scapularis ticks in dogs.Vet Parasitol. 2014 Apr 2;201(3-4):223-5. [2]. Beugnet F, et al. Afoxolaner against fleas: immediate efficacy and resultant mortality after short exposure on dogs.Parasite. 2014;21:42. |
Molecular Formula | C26H17ClF9N3O3 |
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Molecular Weight | 625.87000 |
Exact Mass | 625.08100 |
PSA | 79.79000 |
LogP | 6.71990 |
Packing and Shipping:
afoxolaner insecticide for Dog ,CAT animal with Best Price
Common Name | Afoxolaner | ||
---|---|---|---|
CAS Number | 1093861-60-9 | Molecular Weight | 625.87000 |
Density | N/A | Boiling Point | N/A |
Molecular Formula | C26H17ClF9N3O3 | Melting Point | N/A |
MSDS | N/A | Flash Point | N/A |
Description | Afoxolaner is an orally active isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect γ-aminobutyric acid receptor (GABA) and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod[1][2]. |
---|---|
Related Catalog | Signaling Pathways >> Membrane Transporter/Ion Channel >> Chloride Channel Research Areas >> Infection Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor |
In Vivo | A single oral treatment with a dose approaching the minimum effective dose of afoxolaner (2.5mg/kg) eliminated the pre-existing infestations of I. scapularis ticks and controlled weekly re-infestations, with efficacy between 98% and 100% recorded until Day 23 and 94% at Day 30[1]. |
References | [1]. Mitchell EB, et al. Efficacy of afoxolaner against Ixodes scapularis ticks in dogs.Vet Parasitol. 2014 Apr 2;201(3-4):223-5. [2]. Beugnet F, et al. Afoxolaner against fleas: immediate efficacy and resultant mortality after short exposure on dogs.Parasite. 2014;21:42. |
Molecular Formula | C26H17ClF9N3O3 |
---|---|
Molecular Weight | 625.87000 |
Exact Mass | 625.08100 |
PSA | 79.79000 |
LogP | 6.71990 |
Packing and Shipping: